We are excited to share the progress of our collaborative project, initiated in 2017, which is well on its way to transforming canine models for human health through the creation of a groundbreaking functional annotation of the dog genome! Over the past several years, we have been working to generate the most detailed and comprehensive functional data on the dog genome, enabling ultra-high resolution disease gene mapping that surpasses what was previously possible with existing reference data.
We are already utilizing the new genome annotation to identify risk variants for common brain disorders such as epilepsy, anxiety, and neurodegeneration. Additionally, we are studying variable gene expression in different regions of the brains of dogs and wolves. This project has the potential to transform our understanding of the brain and unlock new possibilities in veterinary and human medicine!
You are welcome to contact us if interested in the project data and prepublication access.
Our specific aims for this project are as follows:
Generate the Most Comprehensive Genome Annotation Atlas for the Dog and Wolf:
We are creating the most complete and detailed genomic atlas for both dogs and wolves, which will serve as a foundational resource for genetic and biomedical research in both species.
Explore Commonalities and Differences Between Human and Dog Genes:
We will analyze and describe the similarities and differences between human and dog genes, including the gene regulatory regions that are crucial for positioning the dog as an effective model for studying human diseases. This will enhance the utility of canine models in translational medicine.
Develop and Provide the Dog Genome Annotation Atlas as a Global Resource:
We will make this dog genome atlas freely available to the global scientific community, housed within a sophisticated and user-friendly DoGA database (DCC), similar to the FANTOM database. This resource will be an invaluable tool for researchers in genomics, veterinary science, and human health.
Leverage New Genomic Resources to Identify Risk Genes and Variants in Canine Brain Disorders:
We will apply this new genomic data to uncover risk genes and variants associated with canine brain disorders, including epilepsy, anxiety, and neurodegeneration. These findings will serve as models for corresponding human conditions, driving advancements in both veterinary and human neurology.
