How to use DoGA Resources

Expression Atlas

To provide end-users with easy and intuitive access to the expression and tissue enrichment of DoGA promoters and genes, we generated an online Shiny app.

The Expression panel allows observation of the expression of a certain promoter in different organ systems and tissues. A gene or promoter can be selected by name or by searching for elements in a specific region.

Tissue Enrichment panels provide access to promoters and genes enriched in specific tissues. One can select a tissue or organ system and obtain a list of the overexpressed genes. The expression of individual genes is visualized by selecting them from the list.

In all panels, one can select a comprehensive or robust dataset with a higher threshold for expression levels and replicability.

We provide the list of diseases and genes taken from OMIA and show their tissue expression in the Disease-Associated Genes tab. This includes searching by disease, gene, or disease subgroups and visualizing the expression as a scatter plot for one gene or a heatmap for multiple ones.

Expression overlapping the SNP clusters from the dog lineage and dog behavior studies is visualized as heatmaps in the SNPs tab. You can select both sets’ subsets of lineage- or behavior-associated SNPs.

You can switch between the robust and comprehensive data set for all tabs, where the comprehensive one contains all promoter regions and the robust only those with replication in at least three samples.